Citation
Pan, X.; Chen, B.; Liu, W.; Li, Y.; Hu, Z.; Lin, X.; Xu, S.; & Peng, X. (2019). Circulating Iron Levels Interaction with Central Obesity on the Risk of Nonalcoholic Fatty Liver Disease: A Case-Control Study in Southeast China. Annals of Nutrition and Metabolism, 74, 207-14.Abstract
Objectives: We aimed to evaluate the associations between body iron stores and the risk of nonalcoholic fatty liver disease (NAFLD) in a Chinese population and explore whether this effect may be modified by other factors.
Methods: 1: 1 frequency-matched case–control study was conducted, including 482 NAFLD cases and 490 gender- and age-matched controls. Serum levels of ferritin, hepcidin, and C-reactive protein were measured.
Results: ultivariate logistic regression analysis showed that hepcidin was not associated with NAFLD risk; however, elevated serum ferritin was significantly associated with increased risk of NAFLD (adjusted OR 1.619, 95% CI 1.158–2.267), and hepcidin:ferritin ratio was significantly associated with decreased risk of NAFLD (ORadjusted 0.702, 95% CI 0.501–0.984). When stratified by gender, a significant association was found between elevated serum ferritin and hepcidin:ferritin ratio and NAFLD only for women (ORadjusted 2.131, 95% CI 1.151–3.944 and ORadjusted 0.414, 95% CI 0.219–0.781, respectively). A significant multiplicative interaction between central obesity and elevated serum hepcidin was observed (p < 0.05).
Conclusions: Elevated serum ferritin and hepcidin:ferritin ratio are associated with NAFLD in a Chinese population. Although serum hepcidin is not associated with NAFLD, it may augment the risk effect of central obesity on NAFLD.
URL
https://doi.org/10.1159/000497228Reference Type
Journal ArticleYear Published
2019Journal Title
Annals of Nutrition and MetabolismAuthor(s)
Pan, X.Chen, B.
Liu, W.
Li, Y.
Hu, Z.
Lin, X.
Xu, S.
Peng, X.